Knowing the risks can help you decide what's best for you. Here are some signs you should look for.
1. Your current job isn't doing the things you want a job to do for you.
2. Your mental health is suffering
3. You are willing to do the hard work of looking for a new job while you still do your old job.
4. You understand taking the chance could be the hardest part.
These are all good. Number 2 seems to be the most important reason to me. I'm grateful I've only had that experience once in 40 years of working.